| Date | Home | Away | Result |
|---|---|---|---|
| 9/12/25 1:30 PM | UD Las Palmas | Real Sociedad B | 2-1 |
| 9/13/25 9:15 AM | CD Mirandes | Deportivo La Coruna | 1-5 |
| 9/13/25 9:15 AM | FC Cadiz | SD Eibar | 1-0 |
| 9/13/25 11:30 AM | SD Huesca | FC Malaga | 1-0 |
| 9/13/25 2:00 PM | Real Valladolid | UD Almeria | 3-1 |
| 9/14/25 7:00 AM | Andorra CF | Cordoba CF | 3-1 |
| 9/14/25 9:15 AM | Racing Santander | CyD Leonesa | 2-4 |
| 9/14/25 11:30 AM | Sporting Gijon | Burgos CF | 2-3 |
| 9/14/25 11:30 AM | CD Castellon | AD Ceuta FC | 3-3 |
| 9/14/25 2:00 PM | FC Granada | CD Leganes | 0-2 |
| 9/15/25 1:30 PM | Real Saragossa | Albacete Balompie | 0-0 |